Therefore, linezolid has the potential for interaction with adrenergic agents, such as the beta-agonists. Vorinostat: (Minor) Beta-agonists may be associated with adverse cardiovascular effects including QT interval prolongation, usually at higher doses and/or when associated with hypokalemia. Beta-agonists may be associated with adverse cardiovascular effects including QT interval prolongation, usually at higher doses and/or when associated with hypokalemia. Beta-agonists may be associated with adverse cardiovascular effects including QT interval prolongation, usually at higher doses, when associated with hypokalemia, or when used with other drugs known to prolong the QT interval. Beta-agonists may be associated with adverse cardiovascular effects including QT interval prolongation, usually at higher doses and/or when associated with hypokalemia. Aspirin, ASA; Butalbital; Caffeine: (Moderate) Sensitive patients may wish to limit or avoid excessive caffeine intake from foods, beverages, dietary supplements and medications during therapy with beta-agonists. Methylxanthine derivatives, (e.g., theophylline, aminophylline) may rarely aggravate the hypokalemic effect seen with beta-agonists. Pitolisant: (Minor) Coadministration of pitolisant and short-acting beta-agonists may increase the risk of QT prolongation. Beta-agonists may be associated with adverse cardiovascular effects including QT interval prolongation, usually at higher doses and/or when associated with hypokalemia. Levothyroxine; Liothyronine (Synthetic): (Moderate) Based on the cardiovascular stimulatory effects of beta-agonists and other sympathomimetics, concomitant use with thyroid hormones might enhance the effects on the cardiovascular system. © document.write(new Date().getFullYear()) PDR, LLC. The pharmacodynamic interaction potential to prolong the QT interval of the electrocardiogram between lefamulin and other drugs that effect cardiac conduction is unknown. A dose of 400 mcg every 2 hours was effective in lowering serum potassium concentrations to less than 5 mmol/L in mechanically ventilated newborns weighing less than 2,000 grams. Carbetapentane; Diphenhydramine; Phenylephrine: (Moderate) Caution and close observation should be used when albuterol is used concurrently with other adrenergic sympathomimetics, administered by any route, to avoid potential for increased cardiovascular effects. This risk may be more clinically significant with long-acting beta-agonists (i.e., formoterol, arformoterol, indacaterol, olodaterol, salmeterol, umeclidinium; vilanterol) than with short-acting beta-agonists. Carbinoxamine; Phenylephrine: (Moderate) Caution and close observation should be used when albuterol is used concurrently with other adrenergic sympathomimetics, administered by any route, to avoid potential for increased cardiovascular effects. Stimulation of beta2-receptors on peripheral vascular smooth muscle can cause vasodilation and a modest decrease in diastolic blood pressure. Dolasetron has been associated with a dose-dependent prolongation in the QT, PR, and QRS intervals on an electrocardiogram. Question: My daughter (who doesn't usually wheeze) is coughing a bunch and wheezing.I gave her some benadryl thinking it was an allergy and was looking to see if an albuterol nebulizer I had (out of date, but functional) might help. Beta-blockers will block the pulmonary effects of inhaled beta-agonists, and in some cases may exacerbate bronchospasm in patients with reactive airways. Caution may be warranted during the administration of high doses in patients with renal impairment, as renal clearance is reduced. Max: 2.5 mg/dose 3 to 4 times daily. Beta-agonists and beta-blockers are pharmacologic opposites, and will counteract each other to some extent when given concomitantly, especially when non-cardioselective beta blockers are used. The R-isomer, known as levalbuterol, is primarily responsible for bronchodilation. At least one case of hypertension occurred in a patient with previous episodes of high blood pressure who was receiving albuterol and selegiline concurrently. Beta agonists infrequently produce cardiovascular adverse effects, mostly with high doses or in the setting of beta-agonist-induced hypokalemia. Glasdegib: (Minor) Consider increased frequency of ECG monitoring if coadministration of glasdegib and short-acting beta-agonists is necessary. Postmarketing data indicate that hydroxyzine causes QT prolongation and TdP. Saquinavir: (Minor) Saquinavir boosted with ritonavir increases the QT interval in a dose-dependent fashion, which may increase the risk for serious arrhythmias such as torsades de pointes (TdP). Beta-agonists and beta-blockers are pharmacologic opposites, and will counteract each other to some extent when given concomitantly, especially when non-cardioselective beta blockers are used. A higher concentration product (0.083% or 0.5% solution for inhalation) may be more appropriate for treatment of acute exacerbations. He is asthmatic so last night we gave him an albuterol treatment through the nebulizer. Monitor the patients lung and cardiovascular status closely. Acetaminophen; Dextromethorphan; Phenylephrine: (Moderate) Caution and close observation should be used when albuterol is used concurrently with other adrenergic sympathomimetics, administered by any route, to avoid potential for increased cardiovascular effects. Sensitive patients might experience tremor, sleep difficulties, or mild increases in heart rate. The mean increase in QTc is about 6 milliseconds, measured at the Tmax of the maximum dosage (1000 mg PO twice daily). Administration via nebulization does not appear to significantly alter the pharmacokinetics of albuterol. The Global Initiative for Asthma (GINA) guidelines recommend 2.5 mg via nebulization with face mask every 20 minutes for the first hour for acute exacerbations, with reassessment thereafter (further dosing not specified). Beta agonists may cause adverse cardiovascular effects, usually with higher doses or when associated with hypokalemia. Therefore, the manufacturer recommends avoiding trazodone in patients receiving other drugs that increase the QT interval. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously with TCAs include the beta-agonists. Beta-agonists may be associated with adverse cardiovascular effects including QT interval prolongation, usually at higher doses and/or when associated with hypokalemia. (Moderate) Beta-agonists are commonly used in conjunction with aminophylline or theophylline therapy. Mefloquine: (Minor) While there is evidence that the use of halofantrine after mefloquine causes a significant lengthening of the QT interval, mefloquine alone has not been reported to cause QT prolongation. The cardiovascular effects of beta-agonists may be potentiated by concomitant use of MAOIs. Beta-agonists can sometimes increase heart rate or have other cardiovascular effects, particularly when used in high doses or if hypokalemia is present. Acetaminophen; Butalbital; Caffeine; Codeine: (Moderate) Sensitive patients may wish to limit or avoid excessive caffeine intake from foods, beverages, dietary supplements and medications during therapy with beta-agonists. Benzphetamine: (Moderate) Caution and close observation should be used when albuterol is used concurrently with other adrenergic sympathomimetics, administered by any route, to avoid potential for increased cardiovascular effects. Monitor blood pressure and heart rate. Beta-agonists should be administered with caution to patients being treated with drugs known to prolong the QT interval because the action of beta-agonists on the cardiovascular system may be potentiated. Answered on Sep 28, 2019 3 doctors agree For the acute treatment of severe episodes, the National Asthma Education and Prevention Program Expert Panel recommends 4 to 8 puffs every 20 minutes for up to 4 hours, then 4 to 8 puffs every 1 to 4 hours as needed. Phentermine: (Moderate) Caution and close observation should be used when albuterol is used concurrently with other adrenergic sympathomimetics, administered by any route, to avoid potential for increased cardiovascular effects. The Global Initiative for Asthma (GINA) guidelines recommend up to 4 to 10 puffs administered with a spacer every 20 minutes for the first hour for mild to moderate exacerbations. Isocarboxazid: (Major) Beta-agonists should be administered with extreme caution to patients being treated with monoamine oxidase inhibitors (MAOIs) due to their sympathomimetic effects. According to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines for COPD, inhaled albuterol may be used as first-line therapy in Group A and may also be used in Groups B, C, and D for additional symptom control. Levomethadyl is contraindicated in combination with other agents that may prolong the QT interval. Children younger than 2 years of age—Use and dose must be determined by your child's doctor. This risk may be more clinically significant with long-acting beta-agonists versus short-acting beta-agonists. Drugs with a possible risk for QT prolongation that should be used cautiously with trifluoperazine include the beta-agonists. Sensitive patients might experience tremor, sleep difficulties, or mild increases in heart rate. Beta-agonists may be associated with adverse cardiovascular effects including QT interval prolongation, usually at higher doses and/or when associated with hypokalemia. Generic:- Protect from light- Store between 36 to 77 degrees F- Store unused product in foil pouchAccuneb:- After removing from pouch, use product within one week- Avoid excessive heat (above 104 degrees F)- Do not store outside the pouch provided- Protect from light- Store between 36 to 77 degrees FProAir digihaler:- Avoid excessive humidity- Store away from excessive heat and cold- Store between 59 to 77 degrees FProair HFA:- Exposure to temperatures above 120 degrees F may cause bursting- Keep away from heat and flame- Store between 59 to 77 degrees F- Store inhaler with mouthpiece downProAir RespiClick:- Avoid excessive humidity- Store away from excessive heat and cold- Store between 59 to 77 degrees FProventil:- Exposure to temperatures above 120 degrees F may cause bursting- Keep away from heat and flame- Store between 59 to 77 degrees F- Store inhaler with mouthpiece downProventil HFA:- Exposure to temperatures above 120 degrees F may cause bursting- Keep away from heat and flame- Store between 59 to 77 degrees F- Store inhaler with mouthpiece downProventil Repetabs:- Protect from light- Store at controlled room temperature (between 68 and 77 degrees F)Respirol :- Exposure to temperatures above 120 degrees F may cause bursting- Keep away from heat and flame- Store between 59 to 77 degrees F- Store inhaler with mouthpiece downVentolin:- Store between 68 to 77 degrees F, excursions permitted 59 to 86 degrees FVentolin HFA:- Exposure to temperatures above 120 degrees F may cause bursting- Keep away from heat and flame- Store between 59 to 77 degrees F- Store inhaler with mouthpiece downVolmax:- Store at controlled room temperature (between 68 and 77 degrees F)VoSpire ER:- Store at controlled room temperature (between 68 and 77 degrees F). Most cases involve patients being treated for pain with large, multiple daily doses of methadone, although cases have been reported in patients receiving doses commonly used for maintenance treatment of opioid addiction. The concomitant use of amiodarone and other drugs known to prolong the QT interval, such as beta-agonists, should only be done after careful assessment of risks versus benefits. We do not record any personal information entered above. Methadone is considered to be associated with an increased risk for QT prolongation and torsade de pointes (TdP), especially at higher doses (> 200 mg/day but averaging approximately 400 mg/day in adult patients). In some patients, 90 mcg (1 puff) every 4 hours may be sufficient. Specific guidelines for dosage adjustments in renal impairment are not available. Quetiapine: (Minor) Limited data, including some case reports, suggest that quetiapine may be associated with a significant prolongation of the QTc interval in rare instances. Carteolol: (Moderate) Use of a beta-1-selective (cardioselective) beta blocker is recommended whenever possible when this combination of drugs must be used together. If metabolic acidosis occurs or persists, consider reducing the dose or discontinuing dichlorphenamide therapy. Send the page "" Drugs with a possible risk for QT prolongation include the beta-agonists. This risk may be more clinically significant with long-acting beta-agonists as compared to short-acting beta-agonists. You can mix Albuterol solvent with pulmicort solvent. Drugs with a possible risk for QT prolongation and TdP that should be used cautiously with ciprofloxacin include the beta-agonists. Amphetamine; Dextroamphetamine Salts: (Moderate) Caution and close observation should be used when albuterol is used concurrently with other adrenergic sympathomimetics, administered by any route, to avoid potential for increased cardiovascular effects. Adjuvant or alternative therapy is warranted for patients experiencing electrocardiographic (ECG) changes or significantly elevated serum potassium concentrations. Monitor the patients lung and cardiovascular status closely. If paradoxical bronchospasm occurs, albuterol should be discontinued immediately and alternative therapy instituted. The action of albuterol inhalation powder should last for 4 to 6 hours. Additive side effects may occur between caffeine and beta-agonists. Androgen deprivation therapy may prolong the QT/QTc interval. Ensure the size is correct. This risk may be more clinically significant with long-acting beta-agonists as compared to short-acting beta-agonists. Carbetapentane; Phenylephrine; Pyrilamine: (Moderate) Caution and close observation should be used when albuterol is used concurrently with other adrenergic sympathomimetics, administered by any route, to avoid potential for increased cardiovascular effects. 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