CDC. Differences in case rates between fully vaccinated persons with and without a booster dose decreased over time; however, more protection was afforded from booster doses, even during Omicron emergence. Alabama, Arkansas, California, Colorado, District of Columbia, Florida, Georgia, Idaho, Indiana, Kansas, Louisiana, Massachusetts, Michigan, Minnesota, Nebraska, New Jersey, New Mexico, New York, New York City (New York), Rhode Island, Seattle/King County (Washington), Tennessee, Texas, Utah, and Wisconsin. Claudia Corwin, MD, MPH, an occupational medicine specialist and associate director of the University Employee Health Clinic, breaks down the biggest differences between delta variant COVID-19 infection in vaccinated and unvaccinated people. The https:// ensures that you are connecting to the CDC charts show how much 2 and 3 doses of COVID vaccine protect from hospitalization. Before On September 24, 2021, CDC recommended a Pfizer-BioNTech booster dose for certain Pfizer-BioNTech primary series recipients, including all adults aged 65 years and persons aged 18 years in certain populations and high risk occupational and institutional settings. This analysis represents the combined impact of BNT162b2 (Pfizer-BioNTech), mRNA-1273 (Moderna), and Ad.26.COV2.S (Janssen [Johnson & Johnson]) COVID-19 vaccines, which had different clinical efficacies against confirmed infection; fully vaccinated persons also include those persons who received additional primary doses and booster doses starting in mid-August. Would you like email updates of new search results? Cases have increased 14% in the last two weeks, city data shows. Of the 378 new COVID-positive hospitalizations statewide for those dates, 97%, or 367 of 378, were people who were either unvaccinated or not yet fully vaccinated, he said. There are many more vaccinated people than there are unvaccinated people, and vaccinated and boosted people are, on average, older and more likely to have underlying health conditions that put them at risk for severe COVID-19 outcomes. Age-standardized case IRRs among unvaccinated persons compared with fully vaccinated persons with a booster dose declined from 13.9 during OctoberNovember to 4.9 during December, representing potential decreases in crude VE for infection from 93% to 80%, respectively. To assess the impact of full vaccination with additional and booster doses (booster doses), case and death rates and incidence rate ratios (IRRs) were estimated among unvaccinated and fully vaccinated adults by receipt of booster doses during pre-Delta (AprilMay 2021), Delta emergence (June 2021), Delta predominance (JulyNovember 2021), and Omicron emergence (December 2021) periods in the United States. A Project of The Annenberg Public Policy Center, This article is available in both English and Espaol, Against earlier forms of the coronavirus, the vaccines were highly effective at preventing symptomatic illness. Against earlier forms of the coronavirus, the vaccines were highly effective at preventing symptomatic illness. These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. During April 4December 25, 2021, a total of 6,812,040 COVID-19 cases among unvaccinated persons and 2,866,517 cases among fully vaccinated persons were reported among persons aged 18 years in 25 U.S. jurisdictions; 94,640 and 22,567 COVID-19associated deaths among unvaccinated and fully vaccinated persons, respectively, were reported by December 4 (Table 1). Data reduction and error analysis for the physical sciences. Anthes, Emily. CDC data compiled from hospitals in 12 states shows that, in the week before Christmas, unvaccinated people ages 50 to 64 were 32 times more likely to be hospitalized with COVID-19 than people in the age range who got a booster shot. Overall, mortality rate was 12.2% (n = 53) and this was higher (16.2%, n = 39) in unvaccinated patients as compared to fully vaccinated patients (6.1%, n = 10, p-value 0.006). Fast HE, Zell E, Murthy BP, et al. Weekly rates of COVID-19 hospitalizations and deaths by vaccination status are published monthly by the Centers for Disease Control and Prevention on its website. 3501 et seq. Despite more breakthrough cases, unvaccinated patients still make up the majority of COVID hospitalizations, according to data from the New Jersey Hospital Association. The COVID-19 case and death rate data by vaccination status were last updated on March 17, and cover April 2021 to Feb. 19 for cases and through Jan. 29 for deaths. Internet bloggers: "Fully vaccinated Australians in hospital for COVID-19 surpass unvaccinated" PolitiFact's ruling: Half True Here's why: Australia faces a surge of COVID-19 cases as the highly contagious omicron COVID-19 variant continues to spread across the continent. CDC is not responsible for the content A COVID-19 case in a fully vaccinated person occurred when SARS-CoV-2 RNA or antigen was detected in a respiratory specimen collected 14 days after completing the primary series of a COVID-19 vaccine with FDA approval or emergency use authorization. The numbers are over the past 30 days: Scott Fallon has covered the COVID-19 pandemic since its onset in March 2020. People who were partially vaccinated are not included in this data. 95% CIs were calculated after detrending underlying linear changes in weekly incidence rates using piecewise linear regression. Eligible persons should stay up to date with COVID-19 vaccinations. Through Monday, 81 per cent of adults 18-plus have received at least one dose, while 73.4 per cent of Ontario's adult population is fully vaccinated. In the U.S., as of September 30, 2021, 56% of the population, 67% of the adults, and 83% of the . The overall crude incidence rates for pneumonia-related-hospitalization and mortality were 1.12 and 0.09 per 1000 patient-years, respectively (Table 2). Questions or messages regarding errors in formatting should be addressed to This finding actually underscores the importance of staying up-to-date on boosters. Three-Week Moving Average Population-Based Rates a of COVID-19Associated Hospitalizations Among Unvaccinated and Vaccinated, MeSH In an email sent to FactCheck.org on March 28, Morefield said he decided to remove his tweet after admitting that the CDC does release some -though not all or enough- data on an agency website. Scott Morefield, the author of the tweet and a weekly columnist for the conservative website Townhall, told us he wrote it after seeing Dr. Aaron Kheriaty on the March 26 episode of Fox News Unfiltered with Dan Bongino.. The state is asking FEMA to send strike forces to bolster hospital staff and National Guard to help depleted nursing home staff as COVID spikes. Generic indicators of ecological resilience: inferring the chance of a critical transition. In all jurisdictions, local health authorities review data to determine whether the death was associated with COVID-19 (through a review of vital records, cause of death, and/or other public health investigations or data sources), though methods vary by state or jurisdiction. To determine characteristics of COVID-19-associated hospitalizations among vaccinated persons and comparative hospitalization rates in unvaccinated and vaccinated persons. The headline of a blog post, published on June 23 by DC Clothesline, reads: "Vaccinated people found to be 600% more likely to die from covid "variants" than unvaccinated people" (archive . Use of wastewater metrics to track COVID-19 in the U.S.: a national time-series analysis over the first three quarters of 2022. When looking at deaths, the difference between being vaccinated and unvaccinated was much more drastic. Murphy, Murphy: No link between wind power and NJ whale deaths, Surprise visit to Ukraine NJ Gov. The site is secure. Posted online June 14, 2022. . For deaths, a single week (November 28December 4, 2021) of data was reported during the December 2021 period of Omicron emergence, but the proportion of Omicron variant during that first week was approximately 1%. Len TM, Dorabawila V, Nelson L, Lutterloh E, Bauer UE, Backenson B, Bassett MT, Henry H, Bregman B, Midgley CM, Myers JF, Plumb ID, Reese HE, Zhao R, Briggs-Hagen M, Hoefer D, Watt JP, Silk BJ, Jain S, Rosenberg ES. Nov 30, 2022. Findings In this cohort study of 173 health care workers, inpatients, and guardians and 45 participants in a community facility, secondary transmission of SARS-CoV . SARS-CoV-2 B.1.1.529 (Omicron) variantUnited States, December 18, 2021. Unable to load your collection due to an error, Unable to load your delegates due to an error. Results: Key Facts. The CDC says, during that same period of time in August, unvaccinated people were 11 times . So vaccination reduces the ICU risk by 93.2 percent. COVID cases rising in NJ are due to the spread of the delta variant among unvaccinated residents, said Gov. -, Butt AA, Talisa VB, Shaikh OS, Omer SB, Mayr FB. Last updated 24 Mar 2022. On November 19, 2021, and November 29, 2021, CDC expanded recommendations for booster doses to include all adults aged 18 years. To interpret IRR changes, age-standardized crude vaccine effectiveness (VE) was estimated as (1 [incidence in vaccinated / incidence in unvaccinated]). Dr Anderson reported grants from Pfizer, Sanofi, GSK, Janssen, MedImmune, Regeneron, PaxVax, Micron, and Merck as well as personal fees from Moderna, Pfizer, Sanofi, GSK, Janssen, Medscape, Kentucky BioProcessing Inc, and WCG and ACI outside the submitted work; additionally, his institution has also received funding from the National Institutes of Health to conduct clinical trials of COVID-19 vaccines. The largest hospitals have seen the highest number of COVID cases among their staff, but not necessarily bypercentage of their workforce. Hospitalized vaccinated persons were older and more likely to have 3 or more underlying medical conditions and be long-term care facility residents compared with hospitalized unvaccinated persons. Vaccination status: A person vaccinated with a primary series had SARS-CoV-2 RNA or antigen detected on a respiratory specimen collected 14 days after verifiably completing the primary series of an FDA-authorized or approved COVID-19 vaccine. The share of COVID-19 hospitalizations by vaccination status in Cosmos data is consistent with a recent CDC MMWR study of 13 jurisdictions, which similarly found fully vaccinated people were 14% of COVID-19 hospitalizations in the June-July period. On November 19, 2021, and November 29, 2021, CDC expanded recommendations for booster doses to include all adults aged 18 years (https://www.cdc.gov/media/releases/2021/s1119-booster-shots.html, https://www.cdc.gov/media/releases/2021/s1129-booster-recommendations.html). Accessed 31 Mar 2022. Excluded were partially vaccinated persons who had received at least one FDA-authorized or approved vaccine dose but did not complete a primary series 14 days before collection of a specimen with SARS-CoV-2 RNA or antigen detected. Of the 8,054 hospitalized breakthrough COVID-19 cases, at least 1,587 deaths are known to have occurred. New Jersey officials called for federal reinforcements to make up for depletion in hospital staff as the virus continues to infect more of them. Results: Using representative data from 192 509 hospitalizations (see Table 1 for demographic information), monthly COVID-19-associated hospitalization rates ranged from 3.5 times to 17.7 times higher in unvaccinated persons than vaccinated persons regardless of booster dose status. Fully vaccinated COVID-19 hospital patients had an aOR of 0.33 for death or the need for invasive mechanical ventilation. Fully vaccinated persons were those with a completed primary series of 2 doses of the Pfizer-BioNTech or Moderna mRNA vaccine or a single dose of the Janssen vaccine (https://www.cdc.gov/coronavirus/2019-ncov/vaccines/stay-up-to-date.html). Analysis periods for this table were designated based on robust reporting of cases among persons with booster doses from October 2021 and the threshold week when the weighted proportions of lineages from whole-genome sequencing results submitted to or performed by CDC: October 3November 27, 2021 (Delta predominance: 99%), and November 28December 25, 2021 (Omicron emergence: 1%72%). 3rd ed. 33.6% were "under-vaccinated," meaning they either received only one shot of the Pfizer or Moderna vaccine, or have not received a booster shot. All eligible persons should stay up to date with COVID-19 vaccination. Those numbers provide only a partial picture of the extent of infections, since they don't include results from at home tests or those who are sick but didn't bother to get tested. Rates of COVID-19 cases and deaths by vaccination status. 81 percent of reported hospitalizations with COVID-19 as the primary diagnosis/cause of admission were in unvaccinated or not fully vaccinated people. They were eight times more likely to be hospitalized with COVID-19 than fully vaccinated people without a booster. SARS-CoV-2 RNA Levels in Wastewater in the United States. Conclusions: Through this preliminary data, we can conclude that patient can develop severe and critical COVID-19 infection despite being vaccinated but this proportion . Monitoring incidence of COVID-19 cases, hospitalizations, and deaths, by vaccination status13 US jurisdictions, April 4July 17, 2021. A survey of hospitals on Dec. 31 showed: The surge has prompted Health Commissioner Judy Persichilli to request reinforcements from the federal government. Atlanta, GA: US Department of Health and Human Services, CDC; 2021. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. An unvaccinated person had SARS-CoV-2 RNA or antigen detected on a respiratory specimen and has not been verified to have received COVID-19 vaccine. Annu Rev Ecol Evol Syst 2015;46:14567. Danza P, Koo TH, Haddix M, Fisher R, Traub E, OYong K, Balter S. MMWR Morb Mortal Wkly Rep. 2022 Feb 4;71(5):177-181. doi: 10.15585/mmwr.mm7105e1. medRxiv. In an analysis, the Post found that if vaccinated people are removed from assessing the data, the case rate for unvaccinated Americans is similar to the case rate for all residents on December 31. Breakthrough disease occurs when a fully vaccinated person experiences symptoms of COVID-19 disease. Substantial case rate increases were recorded among unvaccinated and vaccinated persons when Omicron became the predominant variant in December, resulting in decreased IRRs and declining crude VE estimates (7). A, A spokesperson for the CDC, Kristen Nordlund, told the. As of data received through February 27, 2023, the New York State Department of Health is aware of: 2,767,033 laboratory-confirmed breakthrough cases of COVID-19 among fully-vaccinated people in New York State, which corresponds to 18.8% of the population of fully-vaccinated people 5-years or older. Isnt Publishing Large Portions of the Covid Data It Collects. The New York Times. Published online May 3, 2022. The surge in hospitalizations is projected to peak between 6,000 and 9,000 later this month and is being driven in part by the spread of the omicron variant. Younger Americans Benefited Less From Booster Shots Than Older People. Still, hospitalizations are up 90 percent since July 4, and more than 300 people are now hospitalized in New York City with Covid-19. COVID hospitalization in NJ reach 8-month high. (Note: Hospitalization may or may not have been due to . Thats because vaccination rates have grown only slightly during that period, yet the share of people dying who were vaccinated has risen more steeply (as shown in the chart above). Unauthorized use of these marks is strictly prohibited. The share of hospitalizations among those with COVID-19 who are not fully vaccinated ranged from in 95.02% in Alaska to 99.93% in New Jersey. COVID Data Tracker. COVID-19 is on track to be the third leading cause of death in 2022, for the third year in a row, and this year, about half of those deaths over the course of the year were among people who had at least their primary series. On August 13, 2021, CDC recommended an additional Pfizer-BioNTech or Moderna primary series dose for persons moderately or severely immunocompromised (https://www.cdc.gov/media/releases/2021/s0813-additional-mRNA-mrna-dose.html). A COVID-19 case in a fully vaccinated person with a booster dose occurred when a person had SARS-CoV-2 RNA or antigen detected on a respiratory specimen collected 14 days after receipt of at least one additional or booster dose of any COVID-19 vaccine on or after August 13, 2021. Four analysis periods were designated based on the threshold week when the weighted proportions of lineages from whole-genome sequencing results submitted to or performed by CDC: pre-Delta (April 4May 29, 2021: 0.1%7% proportion range), Delta emergence (May 30July 3, 2021: 14%69%), Delta predominance (July 4November 27, 2021: 81%99%), and Omicron emergence (November 28December 25, 2021: 1%72%). He said we dont know how the COVID-19 vaccines are working in the U.S. because the CDC is no longer releasing their data comparing vaccinated to unvaccinated cases, hospitalizations and deaths. A Facebook post with the video, uploaded to the shows page on March 30, has more than 37,000 views. Krutika Amin Follow @KrutikaAmin on Twitter Vaccines remain highly effective at preventing severe disease, breakthrough infections and disease among vaccinated individuals remain uncommon, and most of the new COVID-19 cases in the U.S. are among unvaccinated people. To subscribe via email notifications, you must first sign in. Murphys green goals for housing, cars, economy get pushback, After NJ teen suicide, Murphy says bullying probe likely as We always look in the mirror, Equal Employment Opportunity Policy and EEO Report. This analysis represents the combined impact of the Pfizer-BioNTech, Moderna, and Janssen COVID-19 vaccines, which had different clinical efficacies against confirmed infection. Rates of COVID-19 Cases and Deaths by Vaccination Status. Posted August 29, 2021. doi: 10.1101 . Why are these basic metrics being withheld from the American people? Kheriaty, published on Feb. 20 that reported the CDC had withheld critical data on boosters, hospitalizations and wastewater analyses. Characteristics of the two groups can be viewed in Table 1. Against omicron, however, the vaccines haventfaredas welland are much worse at preventing infection or mild disease. Marianne Guenot. Against omicron, however, the vaccines havent. The number of observations informing each CI reflects the number of weeks per period: OctoberNovember (7), and December (4). But the VE against infection fell from 91.7% to 79.8%. The C.D.C. The share of COVID-19 deaths among those who are vaccinated has risen. NJ has among lowest gun ownership in U.S. Gov. Open in External Program. Unvaccinated people face a 20 times greater risk of dying from Covid-19 and a 10 times greater risk of testing positive than fully-vaccinated people who have also received a booster, according to . The findings in this report are subject to at least five limitations. By this far into the pandemic, it is estimated that many unvaccinated people have had COVID-19 at least once and while hundreds of thousands of unvaccinated people have needlessly died from COVID, those who survived may have gained some immune protection against the virus that can help protect them against severe outcomes when they have subsequent infections. Morefield, Scott. COVID-19-Associated Hospitalizations Among Adults During SARS-CoV-2 Delta and Omicron Variant Predominance, by Race/Ethnicity and Vaccination Status - COVID-NET, 14 States, July 2021-January 2022. Rates of COVID-19 deaths by vaccination status are reported based on when the patient was tested for COVID-19, not the date they died. Third, national variant prevalence estimates were used, but prevalence differed by jurisdiction over time. Health and Human Services. Among these, encounters discharged from the ED, fully vaccinated but not . 2023 Jan 9;20(2):1182. doi: 10.3390/ijerph20021182. This analysis represents the combined impact of BNT162b2 (Pfizer-BioNTech), mRNA-1273 (Moderna), and Ad.26.COV2.S (Janssen [Johnson & Johnson]) COVID-19 vaccines, which had different clinical efficacies against confirmed infection; fully vaccinated persons also include those persons who received additional primary doses and booster doses starting in mid-August. Information on different FDA-authorized and approved COVID-19 vaccine products, including clinical efficacy, is available online. Corresponding author: Heather M. Scobie, vih8@cdc.gov. During OctoberNovember, unvaccinated persons had 13.9 and 53.2 times the risks for infection and COVID-19associated death, respectively, compared with fully vaccinated persons who received booster doses, and 4.0 and 12.7 times the risks compared with fully vaccinated persons without booster doses. Average weekly, age-standardized rates of cases and deaths (events per 100,000 population) were higher during periods of Delta predominance and Omicron emergence than during pre-Delta and Delta emergence periods and were consistently higher in all periods among unvaccinated persons (range=64.0725.6 [cases] and 1.511.4 [deaths]) than among fully vaccinated persons (range=7.4230.9 and 0.10.7). CDC and other researchers have shown that protection from COVID-19 vaccines can diminish, or wane, over time and booster doses are needed to maintain a robust immune response. References to non-CDC sites on the Internet are URL addresses listed in MMWR were current as of Booster and additional primary dose COVID-19 vaccinations among adults aged 65 yearsUnited States, August 13, 2021November 19, 2021. Variant proportions. that during the omicron wave, adults who had received two doses of the Pfizer/BioNTech or Moderna vaccines had a 79% lower risk of dying or needing a ventilator if hospitalized with COVID-19, compared with unvaccinated adults. The report did say that 83.7% of Covid patients admitted to hospital were unvaccinatedbut this covered the period between 8 December 2020, when vaccination started . Among vaccinated people, cases were low and deaths . In 25 U.S. jurisdictions, decreases in case incidence rate ratios for unvaccinated versus fully vaccinated persons with and without booster vaccine doses were observed when the Omicron variant emerged in December 2021. A graph, with annotations added by Insider, showing US hospitalization . 28 Mar 2022. part 56; 42 U.S.C. *** 45 C.F.R. Ongoing analyses will help monitor the impact of the Omicron variant and other emerging variants on VE against COVID-19 cases and associated deaths; rates by vaccination status will be updated monthly on CDCs COVID Data Tracker website (3). Abbreviations: FDA=Food and Drug Administration; IRR=incidence rate ratio; NC = not calculated for categories with counts <20; NR=not relevant for individual vaccine types because the comparison being made is to overall unvaccinated counts and age-adjusted rates. Phil Murphy. Accessed May 15, 2022. and/or the original MMWR paper copy for printable versions of official text, figures, and tables. On September 24, 2021, CDC recommended a Pfizer-BioNTech booster dose for certain Pfizer-BioNTech primary series recipients, including all adults aged 65 years and persons aged 18 years in certain populations and high risk occupational and institutional settings (https://www.cdc.gov/media/releases/2021/p0924-booster-recommendations-.html). CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. -, Adams K, Rhoads JP, Surie D, et al. MMWR Morb Mortal Wkly Rep. 2021;70(37):1294-1299. doi:10.15585/mmwr.mm7037e3 Among sampled cases, vaccinated hospitalized patients with COVID-19 were older than those who were unvaccinated (median [IQR] age, 70 [58-80] years vs 58 [46-70] years, respectively; P < .001) and more likely to have 3 or more underlying medical conditions (1926 [77.8%] vs 4124 [51.6%], respectively; P < .001). Email sent to FactCheck.org. 2023 Jan 26;12(3):961. doi: 10.3390/jcm12030961. *** https://www.cdc.gov/nchs/data/statnt/statnt24.pdf. To do so, New Jersey needs that extra 150 personnel from FEMA. New Jersey announced 25,277 new cases confirmed by PCR tests Tuesday, the seventh straight day with more than 20,000 new infections, and another 5,137 confirmed through antigen tests. For example, t, showed similar results in its clinical trial, with a. , which was authorized in July 2022, had a 90.4% efficacy in preventing symptomatic COVID-19 in adults, prior to the emergence of the omicron variant. This change requires a reload. Bookshelf January 12, 2022 9:21 AM EST. A COVID-19associated death occurred in a person with a documented COVID-19 diagnosis who died, and whose report local health authorities reviewed (e.g., using vital records, public health investigation, or other data sources) to make that determination. 8600 Rockville Pike Importance: Analysis periods were determined based on variant proportion estimates in the United States. Age-specific vaccine administration data were used for incidence rate denominators; numbers of unvaccinated persons were estimated by subtracting the numbers of fully and partially vaccinated persons from 2019 U.S. intercensal population estimates. A continuity correction assumed at 5% of each age group and jurisdiction would always be unvaccinated (i.e., fully vaccinated coverage 95%). Publishing to the public requires approval. The Moderna vaccineshowed similar results in its clinical trial, with afinalefficacy of93%. Sect. In New Jersey, unvaccinated people were 1,058 times as likely to need hospitalization. Johnson AG, Amin AB, Ali AR, Hoots B, Cadwell BL, Arora S, Avoundjian T, Awofeso AO, Barnes J, Bayoumi NS, Busen K, Chang C, Cima M, Crockett M, Cronquist A, Davidson S, Davis E, Delgadillo J, Dorabawila V, Drenzek C, Eisenstein L, Fast HE, Gent A, Hand J, Hoefer D, Holtzman C, Jara A, Jones A, Kamal-Ahmed I, Kangas S, Kanishka F, Kaur R, Khan S, King J, Kirkendall S, Klioueva A, Kocharian A, Kwon FY, Logan J, Lyons BC, Lyons S, May A, McCormick D; MSHI; Mendoza E, Milroy L, O'Donnell A, Pike M, Pogosjans S, Saupe A, Sell J, Smith E, Sosin DM, Stanislawski E, Steele MK, Stephenson M, Stout A, Strand K, Tilakaratne BP, Turner K, Vest H, Warner S, Wiedeman C, Zaldivar A, Silk BJ, Scobie HM. Excluded were partially vaccinated people who received at least one FDA-authorized vaccine dose but did not complete a primary series 14 days before collection of a specimen where SARS-CoV-2 RNA . The booster dose vaccine type may be different than the primary series vaccine type. The foundation hasno controlover FactCheck.orgs editorial decisions, and the views expressed in our articles do not necessarily reflect the views of the foundation. Ascertaining vaccination status for COVID-19 patients through active linkage of case surveillance and immunization information systems typically assumes that cases among persons who are unmatched to the registry are unvaccinated. That page provides the underlying data for the agencys COVID Data Trackers comparison of COVID-19 cases and deaths by vaccination status. Accessibility However, this protection from a past infection can also diminish over time, which is why it is still recommended that unvaccinated people with prior COVID-19 infections get vaccinated and stay up-to-date on boosters. More transmission can also lead to more deaths. DOI: http://dx.doi.org/10.15585/mmwr.mm7104e2. Hospitalizations have doubled or nearly doubled in Connecticut, Delaware, New Hampshire, New Jersey and New York since Nov. 1. Between August 12, 2021, and December 6, 2021, 10,236 ED encounters with a primary diagnosis of COVID-19 were observed. Protection against infection and death during the Delta-predominant period and against infection during Omicron emergence were higher among booster vaccine dose recipients, especially among persons aged 5064 and 65 years.