Sarcomatoid carcinoma of lung 12. [button] Download the Clinical Trials Mini Magazine [/button] Location: 11 locations, Complementary & Alternative Medicine (CAM), Coping with Your Feelings During Advanced Cancer, Late Effects of Childhood Cancer Treatment, Frederick National Laboratory for Cancer Research, Milestones in Cancer Research and Discovery, Tech Transfer & Small Business Partnerships, Step 1: Application Development & Submission, How to Work With Your Health Insurance Plan, Questions to Ask about Treatment Clinical Trials, Drugs Approved for Different Types of Cancer, Drugs Approved for Conditions Related to Cancer, Targeted Therapy Directed by Genetic Testing in Treating Patients with Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial), Vitamin D3 with Chemotherapy and Bevacizumab in Treating Patients with Advanced or Metastatic Colorectal Cancer, SOLARIS Trial, Nivolumab and Ipilimumab in Treating Patients with Rare Tumors, Trastuzumab and Pertuzumab or Cetuximab and Irinotecan Hydrochloride in Treating Patients with Locally Advanced or Metastatic HER2 / Neu Amplified Colorectal Cancer That Cannot Be Removed by Surgery, Combination Chemotherapy with or without Atezolizumab in Treating Patients with Stage III Colon Cancer and Deficient DNA Mismatch Repair, Savolitinib in Treating Patients with MET Amplified Metastatic or Unresectable Colorectal Cancer, Study of Cabozantinib in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors, Tucatinib Plus Trastuzumab in Patients With HER2+ Colorectal Cancer, Study of TSR-042, an Anti-programmed Cell Death-1 Receptor (PD-1) Monoclonal Antibody, in Participants With Advanced Solid Tumors, Basket Study of Entrectinib (RXDX-101) for the Treatment of Patients With Solid Tumors Harboring NTRK 1 / 2 / 3 (Trk A / B / C), ROS1, or ALK Gene Rearrangements (Fusions), Circulating Tumor DNA Testing in Predicting Treatment for Patients with Stage IIA Colon Cancer After Surgery, COBRA Trial, A Study of a Personalized Cancer Vaccine Targeting Shared Neoantigens, A Study of XmAb®20717 in Subjects With Selected Advanced Solid Tumors, Phase 1 / 2 Study of the Highly-selective RET Inhibitor, Pralsetinib (BLU-667), in Patients With Thyroid Cancer, Non-Small Cell Lung Cancer, and Other Advanced Solid Tumors, A Study of BMS-813160 in Combination With Chemotherapy or Nivolumab in Patients With Advanced Solid Tumors, Transanal Total Mesorectal Excision with Laparoscopic Assistance in Treating Patients with Rectal Cancer, Study of NGM120 in Subjects With Advanced Solid Tumors and Pancreatic Cancer Using Combination Therapy, CPI-006 Alone and in Combination With Ciforadenant and With Pembrolizumab for Patients With Advanced Cancers, A Study of NKTR-262 in Combination With Bempegaldesleukin (NKTR-214) and With Bempegaldesleukin Plus Nivolumab in Patients With Locally Advanced or Metastatic Solid Tumor Malignancies, A Study of TSR-022 in Participants With Advanced Solid Tumors (AMBER), A Phase Ib Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Cibisatamab in Combination With Atezolizumab After Pretreatment With Obinutuzumab in Participants With Previously Treated Metastatic Colorectal Adenocarcinoma, A Study of XmAb®23104 in Subjects With Selected Advanced Solid Tumors (DUET-3), Dose Escalation and Expansion Study of FLX475 Monotherapy and in Combination With Pembrolizumab, Efficacy and Safety Study of Tisotumab Vedotin for Patients With Solid Tumors, U.S. Department of Health and Human Services. VEGF is a substance made by cells that helps the formation of new blood vessels. The study will be conducted in 2 parts. Finding ctDNA in the blood means that there are very likely small amounts of cancer remaining after surgery that may not be detectable using other tests, such as medical imaging. Cetuximab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. In Part B, participants will receive tisotumab vedotin on Days 1, 8, and 15 every 4-week cycle. Patients with genetic abnormalities (such as mutations, amplifications, or translocations) may benefit more from treatment which targets their tumor's particular genetic abnormality. Written by Monica Beyer on May 5, 2019 — Fact checked by Carolyn Robertson. (closed to accrual) 23. Drugs used in chemotherapy, such as TAS-102, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Getting started with the Colorectal Cancer Alliance Clinical Trial Finder is easy! There are two parts to this study. Location: 1201 locations, This phase III trial studies how well vitamin D3 given with standard chemotherapy and bevacizumab works in treating patients with colorectal cancer that has spread to other parts of the body (advanced or metastatic). Identifying these genetic abnormalities first may help doctors plan better treatment for patients with solid tumors, lymphomas, or multiple myeloma. Location: 15 locations, This is a Phase 1 / 2, open-label, first-in-human (FIH) study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antineoplastic activity of pralsetinib (BLU-667) administered orally in patients with medullary thyroid cancer, RET-altered NSCLC and other RET-altered solid tumors. Clear cell cervical cancer 43. The clinical trials on this list are for colorectal cancer. Squamous cell carcinoma with variants of GI tract (stomach small intestine, colon, rectum, pancreas) (closed to accrual 10 / 17 / 2018) 7. Peripheral nerve sheath tumors and NF1-related tumors (closed to accrual 09 / 19 / 2018) 29. This is genetic material unique to the cancer that may be present in the blood stream and can be identified through a ctDNA blood test. The study will be conducted in 2 parts with Part 1 consisting of safety evaluation, pharmacokinetics (PK), and pharmacodynamics (PDy) of escalating doses of dostarlimab. Chemotherapy drugs, such as leucovorin, fluorouracil, and irinotecan, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Spindle cell carcinoma of kidney, pelvis, ureter 20. Intrahepatic cholangiocarcinoma (closed to accrual 03 / 20 / 2018) 10. The study will be conducted in 2 parts, a dose-escalation phase (Part 1) and a cohort expansion phase (Part 2). CPI-006 will be evaluated as a single agent, in combination with ciforadenant (an oral adenosine 2A receptor antagonist), in combination with pembrolizumab (an anti-PD1 antibody), and in combination with ciforadenant and pembrolizumab. 2009;27:3109-3116. Desmoid tumors 28. Location: 14 locations, CO40939 is a Phase Ib, open-label, multicenter, single-arm study designed to evaluate the safety, efficacy, pharmacokinetics, and immunogenicity of cibisatamab in combination with atezolizumab administered after pretreatment with obinutuzumab in patients with Stage IV microsatellite stable (MSS) metastatic colorectal cancer (mCRC) whose tumors have high carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) expression and who have progressed on two or more chemotherapy regimens. The clinical trials on this list are for colorectal cancer. The participants in this trial have HER2-positive (HER2+) metastatic colorectal cancer (mCRC). Location: 8 locations, This phase II trial studies how well retreatment with panitumumab works compared to standard of care regorafenib or trifluridine and tipiracil hydrochloride (TAS-102) in treating patients with colorectal cancer that is negative for RAS wild-type colorectal cancer has spread to other places in the body (metastatic), and / or cannot be removed by surgery (unresectable), and is negative for resistance mutations in blood. This year it’s estimated that more than 100,000 new cases of colon cancer and an estimated 44,180 new cases of rectal cancer will be diagnosed in the U.S., according to the American Cancer … Location: 878 locations, This randomized phase II trial studies how well trastuzumab and pertuzumab work compared to cetuximab and irinotecan hydrochloride in treating patients with HER2 / neu amplified colorectal cancer that has spread from where it started to other places in the body (advanced / metastatic) and cannot be removed by surgery. I.T. Savolitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Location: 28 locations, This is an open-label, multicenter, multinational, Phase 2 basket study exploring the efficacy and safety of neratinib as monotherapy or in combination with other therapies in participants with HER (EGFR, HER2) mutation-positive solid tumors. The clinical trials on this list are for colon cancer treatment. Location: 18 locations, A phase Ib / II, open-label, multicenter, randomized study designed to assess the safety, tolerability, pharmacokinetics and preliminary anti-tumor activity of immunotherapy-based treatment combinations in patients with metastatic colorectal cancer (mCRC) that became refractory to first- and second-line standard therapies. This condition is now also referred to as adenocarcinoma in situ, minimally invasive adenocarcinoma, lepidic predominant adenocarcinoma, or invasive mucinous adenocarcinoma 13. Location: 12 locations, Study of NGM120 in subjects with advanced solid tumors and pancreatic cancer. Location: 5 locations, This is a phase II, open-label, non-randomized study in subjects with histologically confirmed diagnosis of left-sided RAS WT advanced adenocarcinoma of the colon or rectum who have not received prior systemic therapy for metastatic disease. Location: 21 locations, This phase II trial studies how well transanal mesorectal excision with laparoscopic assistance works in treating patients with rectal cancer. Colorectal cancer is a cancer that starts in the colon or the rectum. Location: 741 locations, This phase III trial studies combination chemotherapy and atezolizumab to see how well it works compared with combination chemotherapy alone in treating patients with stage III colon cancer and deficient deoxyribonucleic acid (DNA) mismatch repair. Drugs used in combination chemotherapy, such as oxaliplatin, leucovorin calcium, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether giving high-dose vitamin D3 in addition to chemotherapy and bevacizumab would extend patients time without disease compared to the usual approach (chemotherapy and bevacizumab). Table 3 provides estimated cancer deaths by state in 2019. The study will be conducted in 2 parts: with Part 1 consisting of dose escalation and Part 2 dose expansion. Part 2B of the study will examine the safety and clinical activity of dostarlimab in cohorts of participants with specific types of advanced solid tumors. Participants in Cohort C will receive tucatinib. Subjects enrolled in the SAC cohorts and SAA cohort may receive combination treatment with both cabozantinib and atezolizumab after they experience radiographic progressive disease per the Investigator per RECIST 1.1. Squamous cell carcinoma variants of the genitourinary (GU) system 19. Location: 22 locations, This is a multi-center, open-label, first-in-human Phase 1 study evaluating the anti-programmed death receptor 1 (anti-PD-1) antibody dostarlimab (also known as TSR-042) n participants with advanced solid tumors who have limited available treatment options. The study is composed of a safety run-in and an exploratory part. Clinical trials are research studies that involve people. Vitamin D3 helps the body use calcium and phosphorus to make strong bones and teeth. Colorectal Cancer Facts& Figures 2017-2019 1 Colorectal Cancer Basic Facts What is colorectal cancer? The colon … Drugs used in combination chemotherapy, such as oxaliplatin, leucovorin calcium, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving TAS-102, irinotecan, and bevacizumab may work better in treating patients with colorectal cancer compared to traditional chemotherapy and bevacizumab. Vitamin D3 may also modulate the immune system and is being studied in the prevention and treatment of some types of cancer. In the first part of this study, participants enrolled into Cohort A and received both tucatinib and trastuzumab. Trophoblastic tumor: A) Choriocarcinoma (closed to accrual) 15. Immunotherapy with monoclonal antibodies, such as nivolumab and ipilimumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Vulvar cancer (temporarily closed to accrual) 36. You may want to think about taking part in a clinical trial. Adrenal cortical tumors (closed to accrual 06 / 27 / 2018) 32. Chemotherapy drugs, such as leucovorin calcium, fluorouracil, oxaliplatin, and irinotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Location: 11 locations, This phase Ib / II trial studies the safety and best dose of cabozantinib-s-malate when given together with panitumumab in treating patients with colorectal cancer that has spread to other parts of the body or cannot be removed by surgery. Participants in Cohort C will receive tucatinib. Apocrine tumors / extramammary Paget’s disease (closed to accrual) 40. This new triplet combination for BRAF V600e patients includes: 1. Location: 8 locations, This study evaluates the intratumoral administration of escalating doses of a novel, experimental drug, INT230-6. ctDNA are small pieces of genetic materials (DNA) that are shed by tumors into the blood. Doctors recommend certain screening tests for healthy people with no signs or symptoms in order to look for signs of colon cancer or noncancerous colon polyps. The clinical trials on this list are for colon cancer treatment. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. ctDNA are small pieces of genetic materials (DNA) that are shed by tumors into the blood. In the second part of this study, participants are randomly assigned to either Cohort B or Cohort C. Participants in Cohort B will receive tucatinib and trastuzumab. Participants in Cohort C who do not respond to therapy may have an option to receive tucatinib plus trastuzumab. In Part A, the treatment will be given to participants every 3 weeks (3-week cycles). The Colon Cancer Foundation and the American Cancer Society have joined forces on an initiative called 80% in Every Community, which challenges you to take a stand against one of the most preventable forms of cancer – colorectal cancer – by getting screened, choosing a healthy way of eating and being physically active. Patients with genetic abnormalities (such as mutations, amplifications, or translocations) may benefit more from treatment which targets their tumor's particular genetic abnormality. Giving combination chemotherapy with atezolizumab may work better than combination chemotherapy alone in treating patients with colon cancer. Trastuzumab is a form of “targeted therapy” because it works by attaching itself to specific molecules (receptors) on the surface of cancer cells, known as HER2 receptors. All trials on the list are supported by NCI.. NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. Clinical trials are a type of medical research used to test cutting edge approaches for treating or diagnosing disease, including cancer. High-grade neuroendocrine carcinoma (pancreatic neuroendocrine tumor [PNET] should be enrolled in Cohort 22; prostatic neuroendocrine carcinomas should be enrolled into Cohort 52). Talk to your doctor for help in deciding if one is right for you. Part 1 of the study will be a dose escalation evaluation to determine the maximum tolerated dose (MTD) and to establish a recommended Phase 2 dose (RP2D) of PSB205. In the Phase 2 dose expansion portion, patients will be treated with doublet or triplet in the relapsed / refractory setting and earlier lines of therapy. In Part 2 of the study, subjects will be initially enrolled in Stage 1 of parallel expansion cohorts of FLX475 as monotherapy or in combination with pembrolizumab. Trastuzumab is a form of “targeted therapy” because it works by attaching itself to specific molecules (receptors) on the surface of cancer cells, known as HER2 receptors. Testing for ctDNA levels may help identify patients with colon cancer who benefit from receiving chemotherapy after surgery. Savolitinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Location: 684 locations, The purpose of this study is to evaluate the dose, safety, immunogenicity and early clinical activity of GRT-C903 and GRT-R904, a neoantigen-based therapeutic cancer vaccine, in combination with immune checkpoint blockade, in patients with advanced or metastatic non-small cell lung cancer, microsatellite stable colorectal cancer, pancreatic cancer, and shared neoantigen-positive tumors. Search was performed on 2019 … About 606,880 Americans are expected to die of cancer in 2019 (Table 1), which translates to about 1,660 deaths per day. Location: 901 locations, This phase II trial studies how well savolitinib works in treating patients with MET amplified colorectal cancer that has spread to other places in the body (metastatic) or cannot be removed by surgery (unresectable). When this mutation is present, it switches on pathway called the MAPK pathway which stimulates cell division and leads to uncontrolled cell growth. Finding colon cancer at its earliest stage provides the greatest chance for a cure. In Part 1 of the study, subjects will be enrolled in sequential cohorts treated with successively higher doses of FLX475 as monotherapy or in combination with pembrolizumab. Eligible patients will be assigned to one of several treatment arms. Epithelial tumors of major salivary glands (closed to accrual 03 / 20 / 2018) 3. It is the second leading cause of cancer death among men and women in the U.S, and an estimated one in 20 people will … Extrahepatic cholangiocarcinoma and bile duct tumors (closed to accrual 03 / 20 / 2018) 11. Study, U.S. Department of Health and Human Services. Clinical trials are research studies that involve people. Location: 16 locations, This is a Phase 1, multiple dose, ascending dose escalation study to define a MTD / RD and regimen of XmAb20717, to describe safety and tolerability, to assess PK and immunogenicity, and to preliminarily assess anti-tumor activity of XmAb20717 in subjects with selected advanced solid tumors. After completing the questions, you … Part 2 of the study will further evaluate the RP2D in 3 distinct tumor cohorts of approximately 12 subjects each. Not Otherwise Categorized (NOC) Rare Tumors [To obtain permission to enroll in the NOC cohort, contact: S1609SC@swog.org] (closed to accrual 03 / 15 / 2019) 34. Undifferentiated carcinoma of gastrointestinal (GI) tract 5. Identifying these genetic abnormalities first may help doctors plan better treatment for patients with solid tumors, lymphomas, or multiple myeloma. Colorectal cancer vaccine has promising results in early trials. Angiosarcoma 51. Medical oncologist Rona Yaeger (right) studies signaling pathways in colorectal cancer. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Heating a chemotherapy solution and infusing it directly into the abdomen may kill more cells. When this type of abnormal growth occurs in the colon or rectum, it is called colorectal cancer (CRC). Immunotherapy with monoclonal antibodies, such as panitumumab, may help the body’s immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread Giving cabozantinib-s-malate with panitumumab may work better in treating patients with colorectal cancer. Small cell lung cancer is not eligible (temporarily closed to accrual 03 / 25 / 2020) 52. It works by attaching to and blocking a molecule called PD-1. All registered trials were sorted for tumor type and country/region. A listing of Colorectal Cancer medical research trials actively recruiting patient volunteers. MetaPLASTIC carcinoma (of the breast) (closed to accrual) 37. Treatment with panitumumab may interfere with the ability of tumor cells to grow and spread. Transitional cell carcinoma other than that of the renal, pelvis, ureter, or bladder (closed to accrual) 16. Part 2 of the study will evaluate the antitumor activity of TSR-022, both as monotherapy and in combination with TSR-042 in participants with pre-specified tumor types. Location: 684 locations, This is a Phase 1 / 2, open-label, first-in-human (FIH) study designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antineoplastic activity of pralsetinib (BLU-667) administered orally in patients with medullary thyroid cancer, RET-altered NSCLC and other RET-altered solid tumors. Part 1 consisting of dose escalation and part 2 dose expansion, lymphomas, or treat disease mother of.. 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